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Tuesday, August 4, 2020 | History

2 edition of DNA targeted hypoxic cell radiosensitizers and cytotoxins. found in the catalog.

DNA targeted hypoxic cell radiosensitizers and cytotoxins.

David Stuart Mason Cowan

DNA targeted hypoxic cell radiosensitizers and cytotoxins.

by David Stuart Mason Cowan

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Published .
Written in English


The Physical Object
Pagination226 leaves.
Number of Pages226
ID Numbers
Open LibraryOL17403716M
ISBN 100612026493

DNA-H DNA-H DNA strand breaks Cell death Reduction in hypoxia Oxidation in normoxia DNA DNA-OO irradiation Figure 2. The oxygen fixation hypothesis. Hypoxic tumor cell radiosensitization: role of the iNOS/NO pathway Bull Cancer vol. 95, n° 3, mars Hypoxic Cell Radiosensitizers An alternative approach to the hypoxia problem is the use of chemical agents that mimic oxygen and preferentially sensitize the resistant population to radiation. The advantage of these drugs over oxygen is that they are not rapidly metabolized by the tumor cells through which they diffuse and thus the drugs can.

Each compound was supplemented to myeloma cell lines at a concentration of 10 µM and treated cells were cultured for 5 days under 1% oxygen concentration using a hypoxic culture chamber (Astec, Fukuoka, Japan). Cell lines and cell culture. Two human myeloma cell lines, KMS12PE and U were utilized. Cells were cultured in RPMI medium Cited by: 3. A common feature of tumors is an imbalance between oxygen (O 2) supply and consumption, called hypoxia, the severity of which varies among tumor types [4,5].In tumor tissue, which becomes larger and proliferates, oxygen demand is exceeded by oxygen supply, and the distance between cells and the existing vasculature rises, limiting oxygen : Justyna Żwawiak, Lucjusz Zaprutko.

Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Considered the “gold standard” in the field for over 45 years, Radiobiology for the Radiologist combines traditional and molecular radiation biology principles and appeals to students, residents, and. Bufalin exhibited marked cytotoxicity to MM cells under normoxic and hypoxic conditions. No significant toxicity was observed in lymphocytes obtained from healthy donors. Under normoxic conditions, bufalin induced a DNA double strand break (DSB) response, ROS induction and apoptosis within 24 with a rapid response compared with by: 3.


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DNA targeted hypoxic cell radiosensitizers and cytotoxins by David Stuart Mason Cowan Download PDF EPUB FB2

Hypoxic Cytotoxins. An alternative to radiosensitizing hypoxic tumor cells is to develop a compound that selectively targets hypoxic cells. One common hypoxic cytotoxin is mitomycin C, which is a component of chemotherapy regimens used to treat squamous cell carcinomas of the anal canal.

This drug has also been used as part of chemotherapy. The nitroimidazole-linked phenanthridine series of compounds (NLP-1, 2, and 3) were synthesized under the assumption that it should be possible to enhance the molar efficiency of 2-nitroimidazoles as hypoxic cell radiosensitizers and cytotoxins by targeting them to their likely site of action, DNA.

Hypoxic radiosensitizers and hypoxic cytotoxins in radiation oncology. Weinmann M(1), Welz S, Bamberg M. Author information: (1)Klinik für Radioonkologie, Universität Tübingen, Hoppe-Seyler Str.

3, D Tübingen, Germany. [email protected] Tumor hypoxia is a major constraint for the tumor treatment by by: Abstract. The nitroimidazole-linked phenanthridine series of compounds (NLP-1, 2, and 3) were synthesized under the assumption that it should be possible to enhance the molar efficiency of 2-nitroimidazoles as hypoxic cell radiosensitizers and cytotoxins by targeting them to.

Hypoxic Radiosensitizers and Hypoxic Cytotoxins in Radiation Oncology Article Literature Review in Current Medicinal Chemistry - Anti-Cancer Agents 3(5) October with 36 Reads. It binds to DNA with a binding constant 1 30 that of ethidium bromide.

At a concentration of mM, NLP-1 is 8 times more toxic to hypoxic than aerobic cells at 37°C. This concentration is 40 times less than the concentration of misonidazole, a non-intercalating 2-nitroimidazole, required for the same degree of hypoxic cell by: Fielden E.M., Sapora O.

() Radiation-Induced Cellular DNA Damage and Repair, and the Effect of Hypoxic Cell Radiosensitizers. In: Breccia A., Rimondi C., Adams G.E.

(eds) Advanced Topics on Radiosensitizers of Hypoxic by: 1. Why a cell actively represses these pathways is unclear, although perhaps it is simply an energy saving measure. Importantly, the hypoxia-mediated repression of DNA repair seems to occur at a variety of oxygen tensions i.e.

this does not just occur in regions of severe hypoxia (Cited by:   Hypoxia-activated cytotoxins. Hypoxic tumour cells can be directly targeted using pro-drugs that are metabolically reduced to cytotoxic agents in cells at low oxygen tensions [39, 40]. The use of hypoxia-activated cytotoxins to treat metastatic disease is supported by the detection of hypoxic cells in metastatic tumour foci in a number of pre Cited by: Wardman P.

() Molecular Structure and Biological Activity of Hypoxic Cell Radiosensitizers and Hypoxic-Specific Cytotoxins.

In: Breccia A., Rimondi C., Adams G.E. (eds) Advanced Topics on Radiosensitizers of Hypoxic Cells. NATO Advanced Study Institutes Series (Series A: Life Sciences), vol Springer, Boston, MACited by: Different kinds of cytotoxins work in different ways.

Some cytotoxins make holes in the cell membrane, so the inside of the cell is not protected from the outside. Without a full membrane, the cell dies. Cell death because of this kind of break in the cell membrane is called lysis.

Targeting tumors with hypoxia-activated cytotoxins Article Literature Review in Frontiers in Bioscience 12(9) February with 45 Reads How we measure 'reads'. A hypoxic-ischemic injury is the result of a lack of oxygen, which causes damage to brain cells and the spinal cord.

This type of brain injury is most common before, during, or after childbirth. Hypoxia-induced radioresistance constitutes a major obstacle for a curative treatment of cancer. The aim of this study was to investigate effects of photon and carbon ion irradiation in combination with inhibitors of DNA-Damage Response (DDR) on tumor cell radiosensitivity under hypoxic conditions.

Human non-small cell lung cancer (NSCLC) models, A and H, were irradiated Cited by:   Treatment modalities of head and neck squamous cell cancer include surgery, radiation, chemotherapy, targeted agents and immune checkpoint inhibition. Treatment is often toxic and can affect long-term function and quality of life.

In this context, identification of biomarker data that can help tailor therapy on an individualized basis and reduce treatment-related toxicity would be highly Cited by: 3.

Describe the cascade of cellular events that occur when a cell is hypoxic. Decreased oxygenation to cells and tissues-->decreased mitochondrial oxygen-->decreased ATP (now split to two pathways) First: decreased Na+ pump, increased intracellular Na+, increased extracellular K+, increased intracellular Ca+-->increased H2O-->increased acute cell.

Development of strategies to eradicate radioresistant hypoxic cells would be of great benefit for clinical radiotherapy. In the present study, the in vivo effects of a promising hypoxic cytotoxin, tirapazamine (3-amino-1,2,4 benzotriazine 1,4-di-N-oxide), were examined in comparison with those of KU, one of the best hypoxic cell radiosensitizers, in combination with both single and Cited by: Hypoxic cell radiosensitizers have been tested extensively in the laboratory and in the clinic [].

High LET radiotherapy [47, 48] has been developed partially on the basis of the lower sensitizing effect seen with oxygen for these radiations.

Adjunctive therapy with bioreductive alkylating agents [9, 10], certain. Under hypoxic conditions EGLN2 does not have access to oxygen, and thus does not hydroxylate HIF-1α; HIF-1α subsequently binds to HIF-1β, and the complex acts as a transcription factor on DNA hypoxia-responsive elements (HREs).

Targets include VEGF: promotes angiogenesis; GLUT promotes glycolysis and oxygen-independent ATP production. david lawrence mason has written: 'from buildings and loans to bail-outs: a history of the american savings and loan industry, '.

Sub-regions of hypoxia exist within all tumors and the presence of intratumoral hypoxia has an adverse impact on patient prognosis. Tumor hypoxia can increase metastatic capacity and lead to resistance to chemotherapy and radiotherapy.

Hypoxia also leads to altered transcription and translation of a number of DNA damage response and repair genes. This can lead to inhibition of recombination Cited by:   Radiosensitizers and Biological modifiers in Radiotherapy 1.

RADIOSENSITIZERS Dr. Sandeep Gedela PGIMER, Chandigarh 2. • Radiosensitivity • Relative susceptibility of cells,tissues,organs or organisms to the harmful effect of ionizing radiation • Bergonie and Tribondaeu’s law: Tissues will be more radiosensitive if: I.

The cells are undifferenti. Global 5hmC/C and 5mC/C content of DNA, TET1, TET2 and TET3 mRNA expression and hypoxia marker gene expression in 15 cell lines grown for 24 h under normoxic (21% O 2, white) or hypoxic (% O 2 Cited by: